中文摘要：

妊娠會引發(fā)機(jī)體免疫系統(tǒng)發(fā)生深刻變化。然而，妊娠狀態(tài)下呼吸道針對流感感染的免疫適應(yīng)性變化，及其對疾病嚴(yán)重程度的影響，目前仍尚不明確。

本研究利用妊娠中期臨床前動物模型，揭示了一種鼻腔局部宿主抗甲型流感病毒（IAV）防御增強(qiáng)的分子機(jī)制：該機(jī)制可抑制病毒復(fù)制，并減弱肺內(nèi)免疫應(yīng)答反應(yīng)強(qiáng)度。因此，妊娠小鼠在感染甲型流感病毒后，肺部病理損傷減輕，氣道功能得以維持。

這種對病毒復(fù)制的早期抑制不依賴 I 型干擾素（IFN），而是由鼻腔內(nèi)白介素 - 17 陽性（IL-17?）γδ T 細(xì)胞驅(qū)動 抗菌肽（AMPs） 表達(dá)上調(diào)所介導(dǎo)。妊娠期上呼吸道這套抵御甲型流感病毒感染的宿主防御通路，能夠限制病毒早期侵染、阻止病毒向肺部擴(kuò)散，進(jìn)而維持母體健康狀態(tài)。

英文摘要：

Pregnancy is associated with profound changes in immunity. However, pregnancy-related respiratory immune adaptations in response to influenza infection and their impact on disease severity remain unclear. Here, we describe, in a preclinical model of mid-gestation pregnancy, a mechanism of enhanced host defense against influenza A virus (IAV) localized to the nasal cavity that limits viral replication and reduces the magnitude of intrapulmonary immune responses. Consequently, the pregnant mice show reduced pulmonary pathology and preserved airway function after IAV infection. The early restriction of viral replication is independent of type I interferon (IFN) but dependent on increased antimicrobial peptides (AMPs) driven by interleukin-17+ (IL-17+) γδ+ T cells within the nasal passages. This pathway of host defense against IAV infection in the upper airways during pregnancy restricts early viral infection and prevents virus dissemination into the lung supporting maternal fitness.

論文信息：

論文題目：Pregnancy enhances antiviral immunity independent of type I IFN but dependent on IL-17–producing γδ+ T cells in the nasal mucosa

期刊名稱：Science Advances

時間期卷：Vol 10, Issue 39(2024)

在線時間：2024年9月27日

DOI: 10.1126/sciadv.ado7087

產(chǎn)品信息：

貨號：CP-005-005

規(guī)格：5ml+5ml

品牌：Liposoma

產(chǎn)地：荷蘭

名稱：Clodronate Liposomes&Control Liposomes

辦事處：靶點(diǎn)科技

Clodronate Liposomes氯膦酸鹽脂質(zhì)體在甲型流感病毒感染妊娠小鼠模型種清除肺部巨噬細(xì)胞。荷蘭Liposoma巨噬細(xì)胞清除劑ClodronateLiposomes見刊于Science Advances：妊娠可增強(qiáng)抗病毒免疫，該過程不依賴 I 型干擾素，而依賴鼻黏膜中分泌 IL-17 的 γδ? T 細(xì)胞

Liposoma巨噬細(xì)胞清除劑Clodronate Liposomes氯膦酸二鈉脂質(zhì)體清除巨噬細(xì)胞的材料和方法：

AM depletion

巨噬細(xì)胞清除材料和方法文獻(xiàn)截圖：